Prokineticin GPCR Family Subtypes and Products

What Are Prokineticin Receptors?

Prokineticin receptors are a family of G protein-coupled receptors (GPCRs) comprised of two receptor subtypes: PKR1 and PKR2. Prokineticin receptors play a role in the regulation of a variety of biological processes such as circadian rhythms, GI motility, angiogenesis, hematopoiesis, and neurogenesis. Research, however, is still being done on the biology of this newly discovered family of receptors.

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Prokineticin Receptor Information

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PK1

PK2

Prokineticin receptor 1 (PK1 or GPR73) is a receptor for the cysteine-rich secreted peptides prokineticin 1 and 2. RT-PCR detected GPR73 expression in the brain, testis, small intestine, ovary, thyroid, pituitary and salivary gland.

Prokineticin receptor 2 (PK2 or GPR73L1) is a receptor for the cysteine-rich secreted peptides prokineticin 1 and 2. RT-PCR detected PK2 expression in the brain, testis, small intestine, ovary, thyroid, pituitary, and salivary gland.

Prokineticin Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
ProkineticinPK1humanCHO-K1C1128-1DC1128-1MC1128-1
PK2humanCHO-K1C1127-1DC1127-1MC1127-1
PK2humanCHO-K1C1127-1aDC1127-1aMC1127-1a
PK2 mutanthumanCHO-K1C1127CT-1DC1127DCT-1MC1127MCT-1

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