Peer-Reviewed Papers

FILTER BY GPCR TARGET:

GPCR Target: HEK293T cells overexpressing full-length GIPR or GLP-1R with an N-terminal FLAG tag were purchased from Multispan, Inc

Authors: Dewi Safitri, Matthew Harris, Abigail Pearce, Xianglin Huang, Matthew Rosa, Kerry Barkan, Edward Wills, Maria Marti-Solano, Matthew D. Falk, Graham Ladds

Company:

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom; Pharmacology and Clinical Pharmacy Research Group, Institut Teknologi Bandung, Bandung

40132, Indonesia; Takeda Development Centre Americas Inc, San Diego, CA, USA

GPCR Target: Calcium assay, cAMP assay

Authors: Batran RZ, Gugnani KS, Maher TJ, Khedr MA.

Company: Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre,Dokki, Giza, Egypt; Department of Pharmaceutical Sciences, MCPHS University, Boston, MA, USA.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo, Egypt

Journal: Bioorg Chem. 2021 Jun;111:104817

GPCR Target: Calcium assay

Authors: Aryal P, Syed I, Lee J, Patel R, Nelson AT, Siegel D, Saghatelian A, Kahn BB

Company: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA; Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, California, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

Journal: J Lipid Res. 2021;62:100108.

GPCR Target: CHO-K1-Gαqi5 Gal1R

Authors: Paulo A. De Oliveira, Estefanía Moreno, Nil Casajuana-Martin, Verònica Casadó-Anguera, Ning-Sheng Cai, Gisela Andrea Camacho-Hernandez, Hu Zhu, Alessandro Bonifazi, Matthew D. Hall, David Weinshenker, Amy Hauck Newman, Diomedes E. Logothetis, Vicent Casadó, Leigh D. Plant, Leonardo Pardo, Sergi Ferré

Company: Integrative Neurobiology Section, USA; Medicinal Chemistry Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; Laboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain; Laboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra, Spain; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA; Departments of Pharmaceutical Sciences, Chemistry and Chemical Biology and Center for Drug Discovery, School of Pharmacy at the Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA, USA

Journal: Pharmacological Research, Volume 182, 2022, 106322,

GPCR Target: MOR GTPcS assays were conducted at Multispan Inc. (Hayward, CA) in membranes obtained from stably transfected CHO cell expressing the MOR receptor (CHO-K1 Multispan Inc., C1350-1a) using SPA beads (Perkin Elmer, RPNQ0001).

Authors: Beth Youngblood, Kevin Li, Donald R. Gehlert, Julio C. Medina and Neil Schwartz

Company: Epiodyne Inc., San Francisco, California and R2M Pharma Inc., South San Francisco, California

Journal: Journal of Pharmacology and Experimental Therapeutics August 2021, 378 (2) 133-145

GPCR Target: Antagonist potencies of test items at recombinant dog, rabbit, rat and mouse bradykinin B2 receptors stably expressed in HEK293 cells were determined at Multispan Inc 

Authors: Anne Lesage, François Marceau, Christoph Gibson, Brigitte Loenders, Werner Katzer, Horst-Dieter Ambrosi, Jörn Saupe, Alexander Faussner, Evangelia Pardali, Jochen Knolle

Company: Pharvaris GmbH., Zug, Switzerland; Département de Microbiologie, Infectiologie et Immunologie, Faculté de médecine, Université Laval, Québec, QC G1V 4G2, Canada; AnalytiCon Discovery GmbH, Potsdam, Germany; Pharvaris Netherlands B.V., Leiden, the Netherlands; Faculty of Medicine, Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany

Journal: International Immunopharmacology, Volume 105, April 2022, 108523

GPCR Target: The transfected Chinese hamster ovary-K1 (CHO-K1) Gaqi5 cells with stable S1P1 expression, hS1P1-CHO,

Authors: Jing Jin, Nina Xue, Yuan Liu, Rong Fu, Mingjin Wang, Ming Ji, Fangfang Lai, Jinping Hu, Xiaojian Wang, Qiong Xiao, Xiaoying Zhang, Dali Yin, Liping Bai, Xiaoguang Chen, Shuan Rao,

Company: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100050, China; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR China

Journal: Acta Pharmaceutica Sinica B,Volume 10, Issue 2, February 2020, 

Predictive models to identify small molecule activators and inhibitors of opioid receptors

GPCR Target: The CHO-K1 cells that express full-length human recombinant μ-, κ-, and δ-OPRs (HMOR, HKOR, and HDOR respectively)

Authors: Srilatha Sakamuru, Jinghua Zhao, Menghang Xia, Huixiao Hong, Anton Simeonov, Iosif Vaisman, and Ruili Huang

Company: Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States, Bioinformatics and Computational Biology, School of Systems Biology, College of Science, George Mason University, Manassas, Virginia 20110, United States

Journal: Journal of Chemical Information and Modeling 2021 61 (6), 2675-2685

GPCR Target: CHOK1 stable cell lines, the human MOR, KOR, DOR, and NOP were all inserted into the pMEX2 vector from Multispan (puromycin resistant).  

Authors: Hauge Pedersen M, Pham J, Mancebo H, Inoue A, Asher WB, Javitch JA.

Company: Departments of Psychiatry & Molecular Pharmacology and Therapeutics, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA; 2 Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, USA; 3 NNF Center for Basic Metabolic Research, Section for Metabolic Receptology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; 4 Multispan Inc, Hayward, California, USA; and 5 Department of Pharmacological Sciences, Tohoku University, Sendai, Japan

Journal: J Biol Chem 2022 

GPCR Target: CXCR4

Authors: Katherine Griffithsa, et al.

Company: Dept. of Biochemistry, La Trobe University, Australia.

Journal: JBC Journal of Biological Chemestry. April 1, 2016

GPCR Target: GPR37L1

Authors: Jill H. Dunham, et al.

Company: Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia

Journal: Biochemistry 2009, 48, 43, 10286–10297

GPCR Target: S1P1

Authors: Jing Jin et al.

Company: Institute of Materia Medica, Chinese Academy of Medical Sciences

Journal: Acta Pharmaceutica Sinica B Volume 10, Issue 2, February 2020, 276-288

GPCR Target: GPR37L1

Authors: James L. J. Coleman, et al.

Company: Molecular Cardiology & Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, Australia

Journal: bioRxiv. June 28, 2020.

GPCR Target: Calcium assay

Authors: Anne Lesage, et al.

Company: Pharvaris Netherlands B.V., Leiden, Netherlands

Journal: Frontiers in Pharmacology. June 19, 2020.

GPCR Target: μ/κ/d/Nociceptin

Authors: Maria Hauge Pedersen,  et al.

Company: Columbia University, New York

Journal: bioRxiv . April 10, 2020.

GPCR Target: GPR37L1

Authors: Michelle M.Giddensa, et al.

Company: Emory University School of Medicine / Children’s Mercy Hospital

Journal: Cell Chemical Biology Volume 25, Issue 4, April 19, 2018, 357-369.e6

GPCR Target: SMO

Authors: Susanne Höing, et al.

Company: Max Planck Institute for Molecular Biomedicine / Lead Discovery Center GmbH / Johns Hopkins University / Technische Universität Dortmund / University of Central Florida / University of Münster

Journal: Cell Chemical Biology Volume 25, Issue 4, April 19, 2018, 357-369.e6

GPCR Target: Opioid

Authors: Hee-Kyoung Lee, et al.

Company: The University of Utah / The Walter and Eliza Hall Institute of Medical Research / University of Arizona

Journal: ACS Chem. Biol. 2009, 4, 8, 659-671

GPCR Target: GPR55

Authors: David Baker, et al.

Company: Queen Mary University of London

Journal: British Pharmacology Journals

GPCR Target: SMO

Authors: Floriana Morgillo, et al.

Company: Università della Campania “Luigi Vanvitelli” / Universitàdi Pisa / Universitàdi Napoli

Journal: J. Med. Chem. 2017, 60, 17, 7447-7458

GPCR Target: GLP-1

Authors: Jing Han, et al.

Company: Jiangsu Normal University / Nanjing Medical University / Jiaxing University

Journal: Royal Society of Chemistry

GPCR Target: FFA2

Authors: Stephanie R. Villa, et al.

Company: Northwestern University Feinberg School of Medicine / Vanderbilt University / Indiana University School of Medicine / Multispan Inc. / Midwestern University

Journal: Nature, Scientific Reports volume 6, Article number: 28159 (2016)

GPCR Target: Free Fatty Acid

Authors: Villa SR, et al.

Company: Northwestern University / University of Illinois at Chicago / Midwestern University / Multispan / Jesse Brown Veterans Affairs Medical Center

Journal: J Investig Med. December 2017; 65(8):1116-1124

GPCR Target: MrgX1

Authors: Ajit SK, et al.

Company: Drexel University College of Medicine / Pfizer Global Research and Development

Journal: J Biomed Biotechnol. 2010; pii: 326020

GPCR Target: GnRH

Authors: Richard Fjellaksel, et al.

Company: UiT The Arctic University of Norway / UNN – University Hospital of North-Norway / Oslo University Hospital / University of Oslo / Norsk Medisinsk Syklotronsenter AS

Journal: Royal Society of Chemistry

GPCR Target: GPR55, CB2

Authors: Sofia Sisay, et al.

Company: Queen Mary University of London / University of Aberdeen / University of Toronto / University College London

Journal: PLoS One. 2013; 8(10): e76907

GPCR Target: 79-GPCR panel

Authors: Yuenmu Chen, et al.

Company: Medical College of Wisconsin / University of Texas Southwestern Medical Center

Journal: Biochemistry 2011, 50, 18, 3840-3848

GPCR Target: Cholescystokinin, Nicotinic Acid

Authors: George A. Lemieux, et al.

Company: University of California, San Francisco / SeaChange Pharmaceuticals Inc. / University of North Carolina Medical School

Journal: PLOS Biology

GPCR Target: S1P1

Authors: Jing Jin, et al.

Company: Chinese Academy of Medical Sciences and Peking Union Medical College

Journal: Frontiers in Pharmacology

GPCR Target: P2Y14

Authors: Edyta Gendaszewska-Darmach, et al.

Company: Lodz University of Technology / Polish Academy of Sciences

Journal: Oncotarget. October 25, 2016; 7(43): 69358–69370.

GPCR Target: BLT1/BLT2

Authors: Robert A. Goodnow Jr., et al.

Company: Roche Research Center

Journal: Journal of Medical Chemistry 2010, 53, 9, 3502-3516

GPCR Target: hFFAR2

Authors: Medha Priyadarshini, et al.

Company: Northwestern University

Journal: Molecular Endocrinology, Volume 29, Issue 7, July 1, 2015, 1055–1066

GPCR Target: P2Y

Authors: Edyta Gendaszewska-Darmach, et al.

Company: Institute of Technical Biochemistry

Journal: Purinergic Signalling

GPCR Target: Prostanoid

Authors: William Truong, et al.

Company: Santa Clara University

Journal: Santa Clara University Commons

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