Oxysterol GPCR Family Subtypes and Products

What Are Oxysterol Receptors?

Oxysterol receptors, or Liver X receptors (LXRs), were once in the orphan receptor family, but were de-orphanized once the endogenous ligand, oxysterol, was found. Oxysterol receptors play a role in a variety of biological processes such as glucose homeostasis, cholesterol regulation, and fatty acid regulation. LXRs have found to be involved in the development of certain diseases, such as cardiovascular, eye, and neurodegenerative diseases. LXR agonists have therapeutic utility in the treatment of Alzheimer’s, cardiovascular disease, diabetes, as well as anti-inflammation.

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Oxysterol Receptor Information

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EBI2

Epstein-Barr virus-induced gene 2 (EBI2, also known as GPR183) is a GPCR required for humoral immune responses and polymorphisms have been associated with inflammatory autoimmune diseases. It is expressed in B-lymphocyte cell lines as well as lymphoid tissues but not T-lymphocyte cell lines or peripheral blood T-lymphocytes. 7Į,25-dihydroxycholesterol (7Į,25-OHC) and other oxysterols act as chemoattractants for immune cells expressing EBI2 by directing cell migration. Mice deficient in cholesterol 25- hydroxylase (CH25H, required for generation of 7Į,25-OHC) fail to generate EBI2 biological activity in vivo and shows that the EBI2-oxysterol signaling pathway plays an important role in the adaptive immune response.

Oxysterol Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
Oxysterol	EBI2	human	CHO-K1 Gαqi5	CG1242-1	DCG1242-1	MCG1242-1
	EBI2	mouse	CHO-K1 Gαqi5	CGm1242-1	DCGm1242-1	MCGm1242-1
	EBI2	mouse	CHO-K1	Cm1242-1	DCm1242-1	MCm1242-1