Oxysterol receptors, or Liver X receptors (LXRs), were once in the orphan receptor family, but were de-orphanized once the endogenous ligand, oxysterol, was found. Oxysterol receptors play a role in a variety of biological processes such as glucose homeostasis, cholesterol regulation, and fatty acid regulation. LXRs have found to be involved in the development of certain diseases, such as cardiovascular, eye, and neurodegenerative diseases. LXR agonists have therapeutic utility in the treatment of Alzheimer’s, cardiovascular disease, diabetes, as well as anti-inflammation.
