The neuropeptide S (NPS) receptor is a G protein-coupled receptor (GPCR) found primarily in the central nervous system. Neuropeptide S receptors are involved in many CNS effects, such as arousal and anti-anxiety, and the binding of NPS to NPS receptors also has effects on gastric motility and intestinal permeability. A predisposition to asthma has also been attributed to NPS receptor mutations. Research has also shown a connection between the single-nucleotide polymorphism (SNP) Asn107lle in the NPS receptor to panic disorders, IBS, ADHD, schizophrenia, impulsivity, and sleep.
