General Family Information

Melanin-concentrating hormone receptors are a family of G protein-coupled receptors (GPCRs) comprised of two receptor subtypes: MCH1, found in all mammals, and MCH2, found in some primates and carnivores. Melanin-concentrating hormone receptors have a role in a variety of bodily functions, such as anxiety, appetite control, depression, and stress. Research is being done on the application of MCH1 antagonists in the treatment of various diseases such as depression, anxiety, obesity. MCH1 agonists also have  a possible application in the treatment of insomnia and osteoporosis.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Melanin-Concentrating
Hormone
MCH1humanHEK293T Gαqi5C1031-3DC1031-3MC1031-3
MCH1ratHEK293T Gαqi5C1031-4DC1031-4MC1031-4
MCH2humanCHO dhfr-C1032DC1032MC1032