Melanin Concentrating Hormone GPCR Family Subtypes and Products

What Are Melanin Concentrating Hormone Receptors?

Melanin-concentrating hormone receptors are a family of G protein-coupled receptors (GPCRs) comprised of two receptor subtypes: MCH1, found in all mammals, and MCH2, found in some primates and carnivores. Melanin-concentrating hormone receptors have a role in a variety of bodily functions, such as anxiety, appetite control, depression, and stress. Research is being done on the application of MCH1 antagonists in the treatment of various diseases such as depression, anxiety, obesity. MCH1 agonists also have a possible application in the treatment of insomnia and osteoporosis.

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Melanin Concentrating Hormone Receptor Information

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MCH1

MCH2

MCHR1 or GPR24 is a receptor for melanin-concentrating hormone (MCH). MCH-1R is one of the two MCH receptors identified in human. The primary function of both MCH receptors, MCHR1 and MCHR2, is to regulate skin color. In addition, they also regulate food intake, energy expenditure, behavior and emotion. Blockade of MCHR1 could provide a viable approach for treatment of obesity and certain neurological disorders.

Melanin-concentrating hormone receptor 2 (MCHR2, or GPR145) is the second MCH receptor identified in human. The primary function of both MCH receptors, MCHR1 and MCHR2, is to regulate skin color. In addition, they also regulate food intake, energy expenditure, behavior and emotion.

Melanin Concentrating Hormone Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Melanin-Concentrating HormoneMCH1humanHEK293T Gαqi5C1031-3DC1031-3MC1031-3
MCH1ratHEK293T Gαqi5C1031-4DC1031-4MC1031-4
MCH2humanCHO dhfr-C1032DC1032MC1032

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