MultiScreen™ Beta-Arrestin Sensor
high throughput detection of biased cell signaling
of GPCRs in MultiScreen™ or primary cells
MultiScreen™ Beta-Arrestin Sensor technology
The properties of a ligand that preferentially activates or inhibits one pathway over another are described as cell signaling bias. Screening compounds for biased cell signaling may lead to selective perturbation of disease-specific pathways. Measuring compound activities in cell assays in the same cellular environment, using recombinant or native unmodified GPCRs, is key for accurate cell signaling bias analysis. Our newly developed proprietary MultiScreen™ Beta-Arrestin recruitment assay technology overcomes the receptor-tagging drawback of other technologies, enabling high-throughput detection of beta-arrestin translocation induced by native GPCRs in vitro and in vivo for the first time.