Hydroxycarboxylic Acid GPCR Family Subtypes and Products

Hydroxycarboxylic acid receptors are a family of G protein-coupled receptors (GPCRs) consisting of three receptor subtypes: HCA₁, HCA₂, HCA₃. Hydroxycarboxylic acid receptors all play a role in the mediation of fat cell lipolysis. While most mammals have HCA₁ and HCA₂ receptors, only monkeys, apes, and humans have the HCA₃ receptor. HCA₂ and HCA₃ receptors are thought to play a role in anti-inflammatory effects. Continued research is being done on the medical viability of hydroxycarboxylic acid receptors.