Gonadotrophin-releasing Hormone GPCR Family Subtypes and Products

What Are Gonadotrophin-releasing Hormone Receptors?

Gonadotropin-releasing hormone receptors (GnRHR) are a family of G protein-coupled receptors (GPCRs) comprised of two subtypes in mammals: Type I (GnRH₁) and Type II (GnRH₂). Hypogonadotropic hypogonadism (HH) is attributed to a defect in the GnRHR, and this receptor family plays a key role in the research and treatment of reproduction related conditions. GnRH agonists can result in hypogonadism, but is also used therapeutically for treating hormone-dependent cancers.

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Gonadotrophin-releasing Hormone Receptor Information

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GnRH

FSHR

Gonadotropin-releasing hormone receptor (GnRHR) is a receptor for gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone- releasing hormone (LHRH) and prolactin release-inhibiting factor (PIF). GnRHR is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Gametes and preimplantation embryos also express GnRH and GnRHR. Binding of GnRH to GnRHR causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from gonadotropic cells of the anterior pituitary. Mutations in GnRHR may cause hypogonadotropic hypogonadism and may be associated with anosmia.

Follicle stimulating hormone (FSH) is a gonadotropin hormone secreted by anterior pituitary gonadotropic cells. This glycoprotein plays an important role in: growth, development, pubertal maturation, and reproductive physiology. The FSH receptor (FSHR) is a G protein–coupled receptor that in response to FSH mediates estrogen synthesis and follicular growth in response to FSH.

Gonadotrophin-releasing Hormone Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
Gonadotrophin-Releasing Hormone	GnRH	human	HEK293T	C1283	DC1283	MC1283
	GnRH	dog	HEK293T	Cd1283	DCd1283	MCd1283
	FSHR	human	HEK293T	C1175	DC1175	MC1175