Gonadotrophin-releasing hormone GPCR Family Subtypes and Products
General Family Information
Gonadotropin-releasing hormone receptors (GnRHR) are a family of G protein-coupled receptors (GPCRs) comprised of two subtypes in mammals: Type I (GnRH1) and Type II (GnRH2). Hypogonadotropic hypogonadism (HH) is attributed to a defect in the GnRHR, and this receptor family plays a key role in the research and treatment of reproduction related conditions. GnRH agonists can result in hypogonadism, but is also used therapeutically for treating hormone-dependent cancers.