Ghrelin GPCR Family Subtypes and Products

What Are Ghrelin Receptors?

Ghrelin receptors, also known as growth hormone secretagogue receptors, are a family of G protein-coupled receptors (GPCRs) mainly responsible for regulating body weight and energy homeostasis. Ghrelin receptor agonists have therapeutic applications in muscle degeneration and degenerative diseases, due to their HGH releasing and appetite-stimulating effects. Ghrelin receptor antagonists have therapeutic applications in obesity, due to their anorectic effect.

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Ghrelin Receptor Information

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Ghrelin

The ghrelin receptor is the target of growth hormone secretagogues, a class of synthetic peptide and non-peptide compounds that stimulate growth hormone (GH) release from the anterior pituitary. Ghrelin, the endogenous ligand for the ghrelin receptor, is predominantly secreted from X/A-like cells within the gastric mucosa and may be the source of the majority of circulating plasma ghrelin. Ghrelin stimulates gastric acid secretion and motility, and may have significant effects on appetite and energy. It is not only important for the acute regulation of food intake but also plays an important role in the regulation of long term energy homoeostasis. Ghrelin has a number of actions in cardiovascular system, consistent with the localization of receptors to cardiovascular tissue.

Ghrelin Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
GhrelinGhrelinhumanHEK293TC1197bDC1197bMC1197b
GhrelinhumanCHO-K1C1197-1DC1197-1MC1197-1
GhrelinmouseHEK293TCm1197DCm1197MCm1197

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