Frizzled receptors are a family of G protein-coupled receptors (GPCRs) comprised of ten FZD receptors (FZD1 - FZD10) and the SMO receptor. Frizzled receptors play a role in a variety of biological processes such as cell proliferation and polarity, embryonic development, and neural synapse development. The SMO receptor and its agonists/antagonists are currently being evaluated as cancer drug targets, as SMO is a potential oncogene. SMO is sometimes also deactivated by mutations in the mevalonate pathway, leading to various developmental disorders.
