Bombesin GPCR Family Subtypes and Products

What Are Bombesin Receptors?

Bombesin receptors are a family of G protein-coupled receptors (GPCRs) which consists of 3 mammalian subtypes: BB₁, BB₂, and BB₃ receptors. Both BB₁ and BB₂ are activated by several natural ligands, including neuromedin B and gastrin-releasing peptide. BB₃, however, is an orphan receptor and has no known natural ligand. BB₁ and BB₂ agonists can stimulate tissue growth and muscle contraction, and also have an effect on the central nervous system. Although the exact role of BB₃ is currently unknown, recent studies show a connection to insulin and body temperature regulation. Bombesin receptors could have a major impact in the treatment and detection of human cancers, CNS and behavioral disorders, obesity, and inflammatory conditions like sepsis and arthritis.

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Bombesin Receptor Information

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BB1

BB2

BB3

The human BB1 receptor (or Neuromedin B receptor NMBR) is a receptor for neuromedin-B (NMB), which is a mammalian bombesin-like peptide distributed widely in the central nervous system. The BB1 pathway is involved in the regulation of a wide variety of behaviors, such as spontaneous activity, feeding and anxiety-related behavior. A study using BB1-deficient mice suggested that dysfunction in the BB1 pathway may constitute one of the risk factors of stress vulnerability.

The bombesin BB2 receptor (or gastrin-releasing peptide receptor GRPR) is responsible for many physiological actions such as inhibition of feeding, smooth muscle contraction, exocrine and endocrine secretions, thermoregulation, blood pressure and sucrose regulations, and cell growth. BB2 is expressed in the brain, as well as in colon, lung, and prostate cancer cells. The development of potent receptor antagonists that block BB2 receptor responses has potential for new therapeutic treatments in cancer.

The bombesin receptor subtype 3 (BB3 or BRS3) is expressed in the lung (normal and cancer), nasal mucosa, placenta, and uterus. Mice lacking BB3 receptor develop metabolic defects and obesity phenotype, suggesting that BB3 may be an important target for obesity research. In addition, BB3 may be involved in diabetes and hypertension.

Bombesin Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
Bombesin	BB1	human	HEK293T	C1211	DC1211	MC1211
	BB1	rat	C6	C1211-1	DC1211-1	MC1211-1
	BB2	human	HEK293T	C1215	DC1215	MC1215
	BB3	human	HEK293T	C1214	DC1214	MC1214
	BB3	human	HEK293T	H1214	DH1214	MH1214