Apelin GPCR Family Subtypes and Products

What Are Apelin Receptors

The apelin receptor (APJ), originally designated as an orphan G protein-coupled receptor (GPCR), has the typical 7-transmembrane structure of class A GPCRs, and is comprised of 380 amino acid residues. The receptor has also been found in various other species, such as mouse, rat, cow, and rhesus monkey. APJ plays a role in the regulation of cardiovascular, immunomodulatory, and gastrointestinal function, in addition to fluid homeostasis. APJ has also been discovered to be an HIV co-receptor which, when blocked by apelin peptides, effectively inhibits infection.

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Apelin Receptor Information

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APJ

APJ (also called AGTRL1, angiotensin II receptor-like 1) is a G- protein-coupled receptor that mediates diverse physiological effects of the neuropeptide apelin. It plays a role in the central and peripheral regulation of the cardiovascular system, in water and food intake, and possibly in immune function. APJ is highly expressed in the cardiovascular system and exerts the hypotensive effect in vivo and plays a counter-regulatory role against the repressor action of angiotensin II. APJ is also found to be a coreceptor for the entry of several HIV-1 and SIV strains, and apelin blocks the entry of HIV-1 and HIV-2.

Apelin Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
Apelin	APJ	human	HEK293T	C1196a	DC1196a	MC1196a
Apelin	APJ	human	CHO-K1	C1196-1	DC1196-1	MC1196-1