HUMAN RECOMBINANT NTS1 RECEPTOR
MULTISCREEN™ MEMBRANE PREPARATION
1 vial (9 mg/mL), 1, 5, 10mg
Packaging Buffer: 20mM Gly-Gly, 1 mM MgCl2, 25mM Sucrose (pH 7.2)
Expression vector containing full-length human NTSR1 cDNA (GenBank Accession Number NM_002531.2) with FLAG tag sequence at N-terminus
Liquid nitrogen upon receiving. Avoid repeated freeze-thaw
Background: Human NTS1 is a 418 amino acid transmembrane protein in the neurotensin receptor family. It is primarily expressed in the central nervous system and in peripheral tissues. The neurotensin family plays an important role in a wide range of biological activities, such as hypotension, hyperglycemia, and regulation of vascular permeability. Recent studies have shown that NTS1 antagonists have great potential to become novel drugs for the treatment of neurodegenerative diseases, such as Parkinson’s disease.
Application: Functional assays
Figure 1: Receptor expression on cell surface measured by flow cytometry (FACS) using an anti-FLAG antibody. Thin line: parental cells; thick line: receptor-expressing cells.
Ferraro L, et al. (2009) “Emerging evidence for neurotensin receptor 1 antagonists as novel pharmaceutics in neurodegenerative disorders.” Mini Rev Med Chem. 9(12):1429-38.
Vincent JP, et al. (1999) “Neurotensin and neurotensin receptors.” Trends Pharmacol Sci. 20(7):302-9.
Wikberg JE, et al. (2008) “Targeting melanocortin receptors: an approach to treat weight disorders and sexual disorders.” Nat Rev Drug Discov. 7(4):307-23.