HUMAN RECOMBINANT D2 RECEPTOR

MULTISCREEN™ DIVISION ARRESTED CELL LINE

Product Information

Catalog Number:
DC1336

Lot Number:
031411

Quantity:
1 vial (2 x 106) frozen cells

Freeze Medium:
Sigma Freezing Medium (C-6164)

Host cell:
HEK293T

Transfection:
Expression vector containing full-length human DRD2 cDNA (GenBank accession number NM_000795.3) with FLAG tag sequence at N-terminus

Recommended Storage:
Liquid nitrogen upon receiving

Propagation Medium: DMEM, 10% FBS, 1 μg/mL puromycin

Stability:
Stable for 1-2 days after thawing

Data Sheet

Background: The human dopamine receptor DRD2 (D2) is a G protein-coupled receptor for dopamine. It can be found on postsynaptic dopaminergic neurons that are centrally involved in reward-mediating mesocorticolimbic pathways. Signaling through dopamine D2 receptors governs physiological functions related to locomotion, hormone production, and drug abuse.

Application: Functional assays

References:

Grandy et al. (1989) Cloning of the cDNA and gene for a human D2 dopamine receptor. Proc Nat Acad Sci USA 86:9762-9766.

Neville et al. (2004) Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat 23:540-545.

Usiello et al. (2000) Distinct functions of the two isoforms of dopamine D2 receptors. Nature 408:199-203.

FOR RESEARCH USE ONLY.
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