Product Information
Catalog Number:
MCd1229
Lot Number:
MCd1229-051823
Quantity:
Available 1, 5, or 10mg per vial
Protein concentration: 5.7 mg/mL
Packaging Buffer: 20mM Gly-Gly, 1 mM MgCl2, 25mM Sucrose (pH 7.2)
Host cell:
HEK293T
Transfection:
Expression vector containing full-length Dog CB1 cDNA (GenBank Accession Number XM_038684131.1) with FLAG tag sequence at N-terminus
Recommended Storage:
Liquid nitrogen upon receiving.
Data Sheet
Background: Cannabinoid Receptor 1, CNR1 also known as CB1, is involved in cannabinoid induced CNS effects. It acts by inhibiting intracellular adenylate cyclase activity and could be a receptor for anandamide. CNR1 is a potential target for the development of novel therapeutic drugs in the treatment of various conditions, such as pain, feeding disorders, vascular disease, Parkinson’s disease, and other central nerve system disorders.
Application: Functional assays
Figure 1. Receptor expression on cell surface measured by flow cytometry (FACS) using an anti-FLAG antibody. Thin line: parental cells; thick line: receptor-expressing cells.
References:
Mendizabal and Adler-Graschinsky (2003) Cannabinoid system as a potential target for drug development in the treatment of cardiovascular disease. Curr Vasc Pharmacol 1:301-313.
Gerard et al. (1990) Nucleotide sequence of a human cannabinoid receptor cDNA. Nucleic Acids Res 18:7142.