Protease-activated GPCR Family Subtypes and Products
General Family Information
Protease-activated receptors are a family of G protein-coupled receptors (GPCRs) comprised of four receptor subtypes: PAR1, PAR2, PAR3, and PAR4. These receptors are expressed in cells all throughout the body, primarily in platelets and endothelial cells. PARs are involved in growth, contraction, and hypertrophy in smooth muscles, and play a role in hemostasis and thrombosis. These receptors have also been linked to the inflammation present in atherosclerosis and restenosis.
