Platelet-activating Factor GPCR Family Subtypes and Products

What Are Platelet-activating Factor Receptors?

The platelet-activating factor receptor (PAFR) is a G protein-coupled receptor (GPCR) expressed in a variety of cells within the vascular and immune system. PAFR has been found to play a role in many biological processes such as human reproduction and gas exchange, as well as skin inflammation, carcinogenesis, tumor development, and metastasis. PAFR antagonists have shown potential in the treatment of various tumors as well as skin inflammation.</span>

Click here to view more information about this particular family, including specific subtype information.

Platelet-activating Factor Receptor Information

Clickable Text Interaction

PAF

The platelet-activating factor (PAF) receptor mediates a wide range of biological responses to PAF, a potent glycerophospholipid released from a variety of cell types such as stimulated basophils, platelets, polymorphonuclear neutrophils and macrophages. PAF is involved in a diverse array of biological activities related to inflammatory and immune responses as well as cardiovascular, respiratory and nervous system physiology. In humans, various diseases have been associated with PAF, such as allergic asthma, endotoxic shock, atherosclerosis and psoriasis.

Platelet-activating Factor Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
Platelet-Activating Factor	PAF	human	HEK293T	C1218	DC1218	MC1218