Platelet-activating Factor GPCR Family Subtypes and Products

What Are Platelet-activating Factor Receptors?

The platelet-activating factor receptor (PAFR) is a G protein-coupled receptor (GPCR) expressed in a variety of cells within the vascular and immune system. PAFR has been found to play a role in many biological processes such as human reproduction and gas exchange, as well as skin inflammation, carcinogenesis, tumor development, and metastasis. PAFR antagonists have shown potential in the treatment of various tumors as well as skin inflammation.</span>

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Platelet-activating Factor Receptor Information

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PAF

The platelet-activating factor (PAF) receptor mediates a wide range of biological responses to PAF, a potent glycerophospholipid released from a variety of cell types such as stimulated basophils, platelets, polymorphonuclear neutrophils and macrophages. PAF is involved in a diverse array of biological activities related to inflammatory and immune responses as well as cardiovascular, respiratory and nervous system physiology. In humans, various diseases have been associated with PAF, such as allergic asthma, endotoxic shock, atherosclerosis and psoriasis.

Platelet-activating Factor Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Platelet-Activating FactorPAFhumanHEK293TC1218DC1218MC1218

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