Platelet-activating factor GPCR Family Subtypes and Products
General Family Information
The platelet-activating factor receptor (PAFR) is a G protein-coupled receptor (GPCR) expressed in a variety of cells within the vascular and immune system. PAFR has been found to play a role in many biological processes such as human reproduction and gas exchange, as well as skin inflammation, carcinogenesis, tumor development, and metastasis. PAFR antagonists have shown potential in the treatment of various tumors as well as skin inflammation.