Peer-Reviewed Papers

A novel maintenance therapeutic for opioid use disorder

GPCR Target: MOR GTPcS assays were conducted at Multispan Inc. (Hayward, CA) in membranes obtained from stably transfected CHO cell expressing the MOR receptor (CHO-K1 Multispan Inc., C1350-1a) using SPA beads (Perkin Elmer, RPNQ0001).

Authors: Beth Youngblood, Kevin Li, Donald R. Gehlert, Julio C. Medina and Neil Schwartz

Company: Epiodyne Inc., San Francisco, California and R2M Pharma Inc., South San Francisco, California

Journal: Journal of Pharmacology and Experimental Therapeutics August 2021, 378 (2) 133-145

Year Published: 2021

In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B2 receptor antagonist in clinical development

GPCR Target: Antagonist potencies of test items at recombinant dog, rabbit, rat and mouse bradykinin B2 receptors stably expressed in HEK293 cells were determined at Multispan Inc 

Authors: Anne Lesage, François Marceau, Christoph Gibson, Brigitte Loenders, Werner Katzer, Horst-Dieter Ambrosi, Jörn Saupe, Alexander Faussner, Evangelia Pardali, Jochen Knolle

Company: Pharvaris GmbH., Zug, Switzerland; Département de Microbiologie, Infectiologie et Immunologie, Faculté de médecine, Université Laval, Québec, QC G1V 4G2, Canada; AnalytiCon Discovery GmbH, Potsdam, Germany; Pharvaris Netherlands B.V., Leiden, the Netherlands; Faculty of Medicine, Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany

Journal: International Immunopharmacology, Volume 105, April 2022, 108523

Year Published: 2022

A novel S1P1 modulator IMMH002 ameliorates psoriasis in multiple animal models

GPCR Target: The transfected Chinese hamster ovary-K1 (CHO-K1) Gaqi5 cells with stable S1P1 expression, hS1P1-CHO,

Authors: Jing Jin, Nina Xue, Yuan Liu, Rong Fu, Mingjin Wang, Ming Ji, Fangfang Lai, Jinping Hu, Xiaojian Wang, Qiong Xiao, Xiaoying Zhang, Dali Yin, Liping Bai, Xiaoguang Chen, Shuan Rao,

Company: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100050, China; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR China

Journal: Acta Pharmaceutica Sinica B,Volume 10, Issue 2, February 2020

Year Published: 2020

Predictive models to identify small molecule activators and inhibitors of opioid receptors

GPCR Target: The CHO-K1 cells that express full-length human recombinant μ-, κ-, and δ-OPRs (HMOR, HKOR, and HDOR respectively)

Authors: Srilatha Sakamuru, Jinghua Zhao, Menghang Xia, Huixiao Hong, Anton Simeonov, Iosif Vaisman, and Ruili Huang

Company: Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States, Bioinformatics and Computational Biology, School of Systems Biology, College of Science, George Mason University, Manassas, Virginia 20110, United States

Journal: Journal of Chemical Information and Modeling 2021 61 (6), 2675-2685

Year Published: 2021

A novel luminescence-based β-arrestin recruitment assay for unmodified receptors

GPCR Target: CHOK1 stable cell lines, the human MOR, KOR, DOR, and NOP were all inserted into the pMEX2 vector from Multispan (puromycin resistant).  

Authors: Hauge Pedersen M, Pham J, Mancebo H, Inoue A, Asher WB, Javitch JA.

Company: Departments of Psychiatry & Molecular Pharmacology and Therapeutics, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA; 2 Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, USA; 3 NNF Center for Basic Metabolic Research, Section for Metabolic Receptology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; 4 Multispan Inc, Hayward, California, USA; and 5 Department of Pharmacological Sciences, Tohoku University, Sendai, Japan

Journal: J Biol Chem 2022 

Year Published: 2022

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