Parathyroid Hormone GPCR Family Subtypes and Products

Parathyroid hormone receptors are a family of G protein-coupled receptors (GPCRs) comprised of two receptor subtypes: PTH1 and PTH2. PTH1 is primarily found in both bone and kidney, while PTH2 receptors are mainly concentrated within the central nervous system and pancreas. PTH1 plays a role in the regulation of calcium metabolism, and mutations in the receptor are responsible for disorders such as Jansen’s disease, chondrodysplasia, and enchondromatosis. PTH1 has therapeutic potential in the treatment of osteoporosis, hypoparathyroidism, and various genetic diseases.