Neuropeptide FF/AF GPCR Family Subtypes and Products

What Are Neuropeptide FF/AF Receptors?

Neuropeptide FF (NPFF) receptors are a family of G protein-coupled receptors (GPCRs) comprised of two receptor subtypes: NPFF1 and NPFF2. NPFF1 is primarily found within the central nervous system, more specifically the limbic system and hypothalamus, while NPFF2 is primarily found within the spinal cord. NPFF plays a role in the regulation of food intake, temperature, hormonal modulation, and cardiovascular regulation. Recent studies have also shown a connection between the opioid system and NPFF, suggesting a role for NPFF receptors in drug related conditions. NPFF antagonists also have therapeutic applications in decreasing post-morphine withdrawal symptoms and preventing tolerance to analgesic treatments.

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Neuropeptide FF/AF Receptor Information

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NPFF1

NPFF2

Neuropeptide FF receptor 1 (NPFF1) acts as a modulator of endogenous opioid function. NPFF1 is found across the central nervous system. It is widely expressed in the hypothalamus and limbic system. Recent studies performed on NPPF1 receptors in mice implicate the receptor as an important regulator of body temperature.

Neuropeptide FF receptor 2 (NPFF2) belongs to the rhodopsin family of G protein-coupled receptors and found across the central nervous system. It is believed to regulate endogenous opioid systems in the brain and spinal cord. The neuropeptide is considered a prospective target to decrease negative effects of chronic opioid use.

Neuropeptide FF/AF Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Neuropeptide FF/AFNPFF1humanHEK293TC1363DC1363MC1363
NPFF2humanHEK293T Gαqi5CG1364DCG1364MCG1364

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