General Family Information

Neuromedin U receptors are a family of G protein-coupled receptors (GPCRs) comprised of the receptors NMU1 and NMU2. NMU1 receptors are primarily found within the small intestine, duodenum, and jejunum. Research has recently suggested the involvement of NMU1 receptors in the anorectic actions of neuromedin U. NMU2 receptors are primarily found within the brain, specifically the spinal cord, thalamus, medulla oblongata, substantia nigra, and pontine reticular formation, and are involved in the regulation of energy expenditure and food intake. Neuromedin U is both an NMU1 and NMU2 agonist, while neuromedin S is an NMU2 agonist.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Neuromedin UNMU1humanHEK293TC1122DC1122MC1122
NMU2humanHEK293TC1213DC1213MC1213