Neuromedin U GPCR Family Subtypes and Products

What Are Neuromedin U Receptors?

Neuromedin U receptors are a family of G protein-coupled receptors (GPCRs) comprised of the receptors NMU1 and NMU2. NMU1 receptors are primarily found within the small intestine, duodenum, and jejunum. Research has recently suggested the involvement of NMU1 receptors in the anorectic actions of neuromedin U. NMU2 receptors are primarily found within the brain, specifically the spinal cord, thalamus, medulla oblongata, substantia nigra, and pontine reticular formation, and are involved in the regulation of energy expenditure and food intake. Neuromedin U is both an NMU1 and NMU2 agonist, while neuromedin S is an NMU2 agonist.

Neuromedin U Receptor Information

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NMU1

NMU2

NMUR1, or FM-3 or GPR66, is a receptor for the neuromedin U, a neuropeptide that has been implicated in physiological roles, including the regulation of feeding, anxiety, pain, blood flow, and smooth muscle contraction. The NMUR1 is abundantly expressed in peripheral tissues such as pancreas, testis and small intestine.

NMUR2 is the second receptor for the neuromedin U, which is a neuropeptide and has been implicated in physiological roles, including the regulation of feeding, anxiety, pain, blood flow and smooth muscle contraction. NMUR2 is expressed predominantly in the central nervous system. Central administration of neuromedin U (NMU) suppresses food intake acting through the NMU-2 receptor (NMU2R), which is expressed in the hypothalamus.

Neuromedin U Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Neuromedin UNMU1humanHEK293TC1122DC1122MC1122
NMU2humanHEK293TC1213DC1213MC1213