Neuromedin U GPCR Family Subtypes and Products

Neuromedin U receptors are a family of G protein-coupled receptors (GPCRs) comprised of the receptors NMU1 and NMU2. NMU1 receptors are primarily found within the small intestine, duodenum, and jejunum. Research has recently suggested the involvement of NMU1 receptors in the anorectic actions of neuromedin U. NMU2 receptors are primarily found within the brain, specifically the spinal cord, thalamus, medulla oblongata, substantia nigra, and pontine reticular formation, and are involved in the regulation of energy expenditure and food intake. Neuromedin U is both an NMU1 and NMU2 agonist, while neuromedin S is an NMU2 agonist.