N-formylpeptide Receptor Family Products GPCR Family Subtypes and Products
General Family Information
N-formylpeptide receptors (FPRs) are a family of G protein-coupled receptors (GPCRs) comprised of three receptor subtypes: FPR1, FPR2, and FPR3. FPRs are involved in a variety of cellular functions, such as chemotaxis and the production of superoxides. More specifically, FPR1 has been found to play a role in the host defense against infection, while FPR2 plays a role in inflammation, tumorigenesis, and epithelial cell homeostasis within the colon. FPR3 is still being heavily researched, as not much is known about its pharmacological properties. Further research also needs to be done on N-formylpeptide receptor agonist and antagonist activity.
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