KiSS1-Derived Peptide GPCR Family Subtypes and Products

What Are KiSS1-Derived Peptide Receptors?

The KiSS1-derived peptide receptor is a G protein-coupled receptor (GPCR) involved in the regulation of puberty, fertility, and endocrine function. Agonist activity of the KiSS1 receptor results in the release of gonadotropin-releasing hormones. While full agonists have been identified for the KiSS1 receptor, no antagonists have currently been discovered.

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KiSS1-Derived Peptide Receptor Information

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KiSS1

The Kisspeptin receptor KiSS1 is also known as metastin receptor or GPR54. Kisspeptin is a metastasis suppressor protein that suppresses metastasis in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The KiSS1 receptor is involved in thyroid cancer, esophageal squamous cell carcinoma and hepatocellular carcinoma.

KiSS1-Derived Peptide Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
KiSS1-Derived Peptide	KiSS1	human	CHO dhfr-	C1036	DC1036	MC1036
KiSS1-Derived Peptide	KiSS1	rat	CHO dhfr-	C1036-1	DC1036-1	MC1036-1