Galanin GPCR Family Subtypes and Products

What Are Galanin Receptors?

Galanin receptors are a family of G protein-coupled receptors (GPCRs) comprised of three different receptor subtypes: GAL1, GAL2, and GAL3. Galanin receptors are found all throughout the endocrine, peripheral, and central nervous systems, regulating a variety of biological functions such as arousal, sleep, cognition, reproduction, and metabolic and osmotic homeostasis. Galanin receptor agonists have applications in anti-seizure treatments, while antagonists have potential applications in treatments for anxiety and depression.

Click here to view more information about this particular family, including specific subtype information.

Galanin Receptor Information

Clickable Text Interaction

GAL1/GAL2

The diverse physiological effects of Galanin, a biologically active neuropeptide, are mediated through cell surface G protein-coupled receptors. To date, three galanin receptor subtypes, GAL1, GAL2 and GAL3, have been cloned. Galanin, widely distributed in the central and peripheral nervous systems and the endocrine systems, binds to galanin receptors to induce several regulatory functions in neuronal cells, including neuroregeneration, control of endocrine and exocrine secretions, and modulation of sensory and behavioral functions. Galanin agonists have been shown to have therapeutic application in treatment of chronic pain; galanin antagonists have therapeutic potential in treatment of Alzheimer’s disease, depression, and feeding disorders.

Galanin Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
GalaninGAL1humanCHO-K1 Gαqi5CG1178-1DCG1178-1MCG1178-1
GAL1humanHEK293TC1178DC1178MC1178
GAL2humanCHO-K1C1179-1DC1179-1MC1179-1

Full Catalog