Angiotensin GPCR Family Subtypes and Products

What Are Angiotensin Receptors?

Angiotensin receptors are a family of G protein-coupled receptors (GPCRs) for the renin-angiotensin system, consisting of both angiotensin type 1 (AT₁) receptors, and angiotensin type 2 (AT₂) receptors. Angiotensin II (Ang II) functions as paracrine and autocrine hormones within the brain, heart, kidney, and blood vessels. AT₁ and AT₂ receptors play a role in blood pressure maintenance and glomerular filtration rate.

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Angiotensin Receptor Information

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AT1

AT1 (Angiotensin II, type 1) receptor is an angiotensin receptor with vasopressor effects and regulates aldosterone secretion. It is essential in controlling blood pressure and volume in the cardiovascular system. AT1 receptor antagonists are drugs useful in the treatment of hypertension, diabetic nephropathy and congestive heart failure. Blockade of AT1 receptors could also be a novel approach in the treatment of mood disorders and neurodegenerative diseases of the brain.

Angiotensin Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
Angiotensin	AT1	human	HEK293T	H1417	DH1417	MH1417
	AT1	human	HEK293T	HA1417- BA1	DHA1417- BA1	MHA1417- BA1
	AT1	human	HEK293T	HA1417-BA2	DHA1417-BA2	MHA1417-BA2