Angiotensin GPCR Family Subtypes and Products

What Are Angiotensin Receptors?

Angiotensin receptors are a family of G protein-coupled receptors (GPCRs) for the renin-angiotensin system, consisting of both angiotensin type 1 (AT1) receptors, and angiotensin type 2 (AT2) receptors. Angiotensin II (Ang II) functions as paracrine and autocrine hormones within the brain, heart, kidney, and blood vessels. AT1 and AT2 receptors play a role in blood pressure maintenance and glomerular filtration rate.

Click here to view more information about this particular family, including specific subtype information.

Angiotensin Receptor Information

Clickable Text Interaction

AT1

AT1 (Angiotensin II, type 1) receptor is an angiotensin receptor with vasopressor effects and regulates aldosterone secretion. It is essential in controlling blood pressure and volume in the cardiovascular system. AT1 receptor antagonists are drugs useful in the treatment of hypertension, diabetic nephropathy and congestive heart failure. Blockade of AT1 receptors could also be a novel approach in the treatment of mood disorders and neurodegenerative diseases of the brain.

Angiotensin Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
AngiotensinAT1mouseCHO-K1Cm1417-1DCm1417-1MCm1417-1
AT1mouseCHO-K1Cm1417-1aDCm1417-1aMCm1417-1a
AT1humanHEK293TH1417DH1417MH1417
AT1humanHEK293THA1417- BA1DHA1417- BA1MHA1417- BA1
AT1humanHEK293THA1417-BA2DHA1417-BA2MHA1417-BA2

Full Catalog