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Adhesion receptors are a family of G protein-coupled receptors (GPCRs) that consists of 33 human protein receptors, a majority of which are orphan receptors. Work is being done to de-orphanize these. While ligands for many of these receptors remains unknown, ligand profiles and in vitro studies have shown a role for adhesion GPCRs in cell adhesion and migration, and the proper positioning of cells in various organ systems. There is growing evidence that also suggests a relationship in tumour cell metastasis.