Adhesion GPCR Family Subtypes and Products

What Are Adhesion Receptors?

Adhesion receptors are a family of G protein-coupled receptors (GPCRs) that consists of 33 human protein receptors, a majority of which are orphan receptors. Work is being done to de-orphanize these. While ligands for many of these receptors remains unknown, ligand profiles and in vitro studies have shown a role for adhesion GPCRs in cell adhesion and migration, and the proper positioning of cells in various organ systems. There is growing evidence that also suggests a relationship in tumour cell metastasis.

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Adhesion Receptor Information

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GPR97

GPR110

Human G-protein coupled receptor 97 (ADGRG3), a member of the adhesion GPCR family, is a recently deorphanzied receptor for beclomethasone dipropionate. GPR97 is expressed in immune cells, specifically thymocytes and pre-B cells. Current research studies on knockout mice demonstrate the importance of GPR97 in B-cell development and its potential as a therapeutic target for the treatment of immunological disorders.

GPR110 is an orphan G protein-coupled receptor. In a retroviral insertion mutagenesis screen in mouse, GPR110 has been identified as an oncogene. GPR110 has also been demonstrated as the synaptamide receptor, mediating synaptamide-induced bioactivity in a cAMP-dependent manner.

Adhesion Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Adhesion Class GPCRsGPR97humanHEK293TC1396DC1396MC1396
GPR110humanHEK293TC1378DC1378MC1378

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