Trace amine GPCR Family Subtypes and Products

What Are Trace amine Receptors?

Trace amine receptors are a family of G protein-coupled receptors (GPCRs), however only one receptor, TA1, from the family has been sufficiently researched. Trace amine receptors have potential pharmacological application in the treatment of psychological, neurological, and amphetamine related disorders. TA1 receptor agonists, such as tyramine and amphetamine, have been discovered, although research is still being done on their exact pharmacological role.

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Trace amine Receptor Information

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TA1

TAAR1 (Trace Amine Receptor 1) or TA1 is a receptor for trace amines. The receptor can be activated by endogenous trace amines as well as metabolites of the biogenic amine neurotransmitters. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Trace amine receptors are potential direct targets for drugs of abuse, including amphetamine and 3,4-methylenedioxymethamphetamine (MDMA).

Trace amine Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Trace AmineTA1ratHEK293TC1357DC1357MC1357
TA1humanHEK293TC1357aDC1357aMC1357a
TA1ratHEK293T Gαqi5Cr1357DCr1357MCr1357

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