Prolactin-releasing Peptide GPCR Family Subtypes and Products

What Are Prolactin-releasing Peptide Receptors?

The prolactin-releasing peptide (PrRP) receptor is a G protein-coupled receptor (GPCR) found within various regions of the brain, and once belonged to the orphan class of GPCRs. It is suspected that PrRP receptors have some function in breast cancer and human tumor development, and more recent students have shown that these receptors play a role in inflammatory and immune response for autoimmune disorders, such as arthritis and lupus. Research is being done into the role of PrRP receptors in recurrent miscarriages, preeclampsia, and peripartum cardiomyopathy, although exact etiology and mechanisms are currently unknown.

Prolactin-releasing Peptide Receptor Information

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Prolactin-releasing peptide receptor PRRP (or GPR10) is detected in human brain, pituitaries, normal portions of adrenal glands and various tumor tissues. High level of expression is detected in pheochromocytomas. GPR10 was investigated regarding the effect of normal and high-fat diets on energy intake, body weight, and glucose homeostasis in wild-type and GPR10 knockout mice. The investigation provided direct evidence that GPR10 is involved in the regulation of energy balance.

Prolactin-releasing Peptide Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Prolactin-Releasing PeptidePrRPhumanCHO dhfr-C1037DC1037MC1037