Orexin GPCR Family Subtypes and Products

What Are Orexin Receptors?

Orexin receptors are a family of G protein-coupled receptors (GPCRs) comprised of two receptor subtypes: OX1 and OX2. Orexin receptors play a role in appetite, alertness, and wakefulness. The human narcolepsy disorder can be attributed to orexin neuron loss. Orexin receptor agonists currently have pharmacological potential in the treatment of narcolepsy, while orexin receptor antagonists show therapeutic value in the treatment of insomnia.

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Orexin Receptor Information

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OX1

OX2

Orexins, or hypocretins, produced by a small group of neurons in lateral hypothalamus, are involved in many physiological functions such as feeding, energy metabolism, sleep, arousal, reward, substance abuse, stress, as well as sympathetic and cardiovascular functions. OX1 is one of the two receptors for the orexins. The receptor is expressed in the brain regions such as the hypothalamus, hippocampus and thalamus. Recent studies have indicated that orexins may also be useful in the treatment of schizophrenia and other psychiatric disorders.

OX2 is one of the two receptors for the orexins. The receptor is expressed in the brain regions such as the hypothalamus, hippocampus and thalamus. Recent studies have indicated that orexins may also be useful in the treatment of schizophrenia and other psychiatric disorders.

Orexin Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
OrexinOX1humanCHO-K1C1033-1DC1033-1MC1033-1
OX2humanCHO-K1C1034-1DC1034-1MC1034-1

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