Orexin receptors are a family of G protein-coupled receptors (GPCRs) comprised of two receptor subtypes: OX1 and OX2. Orexin receptors play a role in appetite, alertness, and wakefulness. The human narcolepsy disorder can be attributed to orexin neuron loss. Orexin receptor agonists currently have pharmacological potential in the treatment of narcolepsy, while orexin receptor antagonists show therapeutic value in the treatment of insomnia.
