Nicotinic Acid GPCR Family Subtypes and Products

Nicotinic acid receptors, also known as hydroxycarboxylic acid (HCA) receptors, are a family of G protein-coupled receptors (GPCRs) comprised of three receptor subtypes: HCA1, HCA2, and HCA3. These receptors play a role in the modulation of antilipolytic effects within fat cells. While HCA1 and HCA2 are present in most mammals, only higher primates possess HCA3 receptors. Research is being done into the potential of HCA receptors as anti-inflammatory treatments.