New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways.

GPCR Target: Calcium assay, cAMP assay

Authors: Batran RZ, Gugnani KS, Maher TJ, Khedr MA.

Company: Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre,Dokki, Giza, Egypt; Department of Pharmaceutical Sciences, MCPHS University, Boston, MA, USA.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo, Egypt

Journal: Bioorg Chem. 2021 Jun;111:104817