Motilin GPCR Family Subtypes and Products

What Are Motilin Receptors?

The motilin receptor is a G protein-coupled receptor (GPCR) that binds the endogenous ligand motilin. Motilin is involved in the stimulation of smooth muscle contraction within the gut. Research is also being done into the role of motilin receptors in the prokinetic effects of macrolide antibiotics.

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Motilin Receptor Information

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Motilin

Motilin is a 22-amino acid peptide hormone that is expressed throughout the gastrointestinal (GI) tract as well as in enteric neurons of the duodenum and colon. It plays an important role in gastric motility by stimulating interdigestive antrum and duodenal contractions. Development of motilin receptor agonists or antagonists could be useful in the treatment of GI disorders.

Motilin Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
MotilinmotilinhumanHEK293TH1297H1297H1297

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