Glycoprotein Hormone GPCR Family Subtypes and Products

What Are Glycoprotein Hormone Receptors?

Glycoprotein hormone receptors are a family of G protein-coupled receptors (GPCRs) comprised of three main hormone receptor subtypes: follitropin (FSH), lutropin (LH), and thyrotropin (TSH) hormone receptors. Monoclonal antibodies that activate the TSH receptor have already been produced as a treatment for Graves’ disease.

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Glycoprotein Hormone Receptor Information

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TSH

The thyroid stimulating hormone receptor (TSHR) is expressed in the membrane of thyroid follicular cells. It is involved in regulating thyrocyte cell growth and function. TSHR is also the target autoantigen in thyroid autoimmune diseases. Autoantibodies to TSHR that act as agonists are responsible for the hyperthyroidism of Graves’ Disease. Another class of autoantibodies that block the binding of TSH to TSHR may mediate the hypothyroidism associated with Hashimoto’s thyroiditis, primary myxoedema, and neonatal hypothyroidism.

Glycoprotein Hormone Cell Lines

Receptor Family	Receptor	Species	Parental	Stable Cell Lines	Division-Arrested Cells	Membranes
Glycoprotein Hormone	TSH	human	HEK293T	H1177	DH1177	MH1177
Glycoprotein Hormone	TSH	rat	HEK293T	C1177-1	DC1177-1	MC1177-1