Glycoprotein Hormone GPCR Family Subtypes and Products

What Are Glycoprotein Hormone Receptors?

Glycoprotein hormone receptors are a family of G protein-coupled receptors (GPCRs) comprised of three main hormone receptor subtypes: follitropin (FSH), lutropin (LH), and thyrotropin (TSH) hormone receptors. Monoclonal antibodies that activate the TSH receptor have already been produced as a treatment for Graves’ disease.

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Glycoprotein Hormone Receptor Information

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TSH

The thyroid stimulating hormone receptor (TSHR) is expressed in the membrane of thyroid follicular cells. It is involved in regulating thyrocyte cell growth and function. TSHR is also the target autoantigen in thyroid autoimmune diseases. Autoantibodies to TSHR that act as agonists are responsible for the hyperthyroidism of Graves’ Disease. Another class of autoantibodies that block the binding of TSH to TSHR may mediate the hypothyroidism associated with Hashimoto’s thyroiditis, primary myxoedema, and neonatal hypothyroidism.

Glycoprotein Hormone Cell Lines

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Glycoprotein HormoneTSHhumanHEK293TH1177DH1177MH1177
TSHratHEK293TC1177-1DC1177-1MC1177-1

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