Custom Kinase Cell-Based Assay Development

Kinases are central regulators of intracellular signaling and are among the largest drug targets in modern medicine.

Over the past 24 years, 88 kinase inhibitors have been approved by the FDA—mostly for oncology— highlighting a strong cancer focus and untapped opportunities in other diseases.
Click to view opportunities for kinase inhibitors beyond oncology:
Kinases are central regulators of intracellular signaling and are among the largest drug targets in modern medicine.
Over the past 24 years, 88 kinase inhibitors have been approved by the FDA—mostly for oncology— highlighting a strong cancer focus and untapped opportunities in other diseases.
Click to view opportunities for kinase inhibitors beyond oncology:

The Case for Cell-Based Kinase Assays

Early screening through precision medicine.
Guiding discovery with results that translate.

Cell-Based vs. Biochemical Kinase Assays

Biochemical Kinase Assays
  • Conducted outside native cellular context
  • Miss protein-protein interactions, compartmentalization
  • Fail to account for metabolism, cell membrane penetrance, efflux pumps, feedback loops
  • Risk false positives/negatives
Cell-Based Kinase Assays
  • Reflect native kinase environment with cofactors and substrates
  • Evaluate permeability, bioavailability, metabolic stability
  • Pathway-specific readouts (e.g.,phosphorylation, reporter expression)
  • Better prediction of in vivo efficacy
  • Align responses with clinical biomarkers
Custom Cell-Based Assay Development

Our Custom Kinase Assay Advantage
"We make it work successfully every time"

20 Years of Experience

2,000+ Potency HTS Assays

We're a Trusted Leader in Custom Cell-Based Kinase Assay Development

We combine pharmacological precision with cell-engineering expertise to deliver reproducible, biologically relevant results that accelerate discovery from target to IND.
We have developed a diverse family of kinases such as AMPK, TrkA, FGFR3, and DNA-PK, supporting both receptor tyrosine kinases (RTKs) and serine/threonine kinase programs, in native cells or recombinant stable clones.

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