Corticotropin-Releasing Factor GPCR Family Subtypes and Products

General Family Information

Corticotropin-releasing factor receptors (CRFRs) are a family of G protein-coupled receptors (GPCRs) comprised of two receptor types: CRF1 and CRF2. CRFRs play an important role in the activation of the autonomic stress response. CRFRs bind corticotropes, secreting adrenocorticotropic hormones, and as a result, activating the hypothalamic-pituitary-adrenal axis, which is part of the fight-or-flight response. Constant activation of CRFRs have also been shown to have an impact on the development of anxiety and learning impairments from early life to adulthood.

Receptor FamilyReceptorSpeciesParentalStable Cell Lines Division-Arrested Cells Membranes
Corticotrophin-Releasing FactorCRF1humanHEK293TC1040DC1040MC1040
CRF1humanHEK293T Gαqi5CG1040DCG1040MCG1040