Corticotropin-Releasing Factor GPCR Family Subtypes and Products
General Family Information
Corticotropin-releasing factor receptors (CRFRs) are a family of G protein-coupled receptors (GPCRs) comprised of two receptor types: CRF1 and CRF2. CRFRs play an important role in the activation of the autonomic stress response. CRFRs bind corticotropes, secreting adrenocorticotropic hormones, and as a result, activating the hypothalamic-pituitary-adrenal axis, which is part of the fight-or-flight response. Constant activation of CRFRs have also been shown to have an impact on the development of anxiety and learning impairments from early life to adulthood.