MULTISCREEN™ MEMBRANE PREPARATION

HUMAN RECOMBINANT MGLUR2 RECEPTOR

Product Information

Catalog Number:
MC1189a

Lot Number:
MC1189a-06262013

Quantity:
12.46mg/ml

Host cell:
HEK293T

Transfection:
Expression vector containing full-length human GRM2 cDNA with FLAG tag sequence at N- terminus

Recommended Storage:
Liquid nitrogen upon receiving

Data Sheet

Background: The neurotransmitter L-glutamate interacts with both ionotropic and metabotropic receptors. The metabotropic glutamate receptors (mGluRs), which are G protein-coupled receptors, have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group II and group III mGluRs are linked to the inhibition of the cyclic AMP cascade, but differ in their agonist selectivity. The mGluR2 is a member of group II metabotropic glutamate receptors.

Figure 1. Receptor expression on cell surface measured by flow cytometry (FACS) using an anti-FLAG antibody. Thin line: parental cells; thick line: receptor-expressing cells.

References:

Flor et al. (1995) Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. Eur J Neurosci 7:622-629.

FOR RESEARCH USE ONLY.
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