Product Information
Catalog Number:
C1307
Lot Number:
C1307-082509
Quantity:
1 vial (2 x 106) frozen cells
Freeze Medium:
Sigma Freezing Medium (C-6164)
Host cell:
HEK293T
Transfection:
Full-length human CYSLTR2 cDNA (GenBank Accession Number NM_020377)
Recommended Storage:
Liquid nitrogen upon receiving
Propagation Medium: DMEM, 10% FBS, 200 µg/mL hygromycin
Stability:
Stable after minimum two months continuous growth
Data Sheet
Background: Cysteinyl leukotriene receptor 2 (CysLTR2) is a receptor for cysteinyl leukotrienes. There are two receptors for cysteinyl leukotrienes, CysLTR1 and CysLTR2. CysLTRs have a clear role in pathophysiological conditions such as asthma, allergic rhinitis and other nasal allergies, and have been implicated in a number of inflammatory conditions in cardiovascular and gastrointestinal diseases.
Application: Functional assays
Figure 1. Dose-dependent calcium flux upon treatment with ligand, measured with MultiscreenTM Calcium 1.0 No Wash Assay Kit (Multispan MSCA01).
References:
Takasaki et al. (2000) The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. Biochem Biophys Res Commun 274:316-322.
Capra (2004) Molecular and functional aspects of human cysteinyl leukotriene receptors. Pharmacol Res 50:1-11.