MULTISCREEN™ MEMBRANE PREPARATION

HUMAN RECOMBINANT RXFP3 RECEPTOR

Product Information

Catalog Number:
MC1306

Lot Number:
MC1306-032414

Quantity:
13.9 mg/ml, 10 mg

Packaging Buffer:
20 mM Gly-Gly, 1 mM MgCl2, 25 mM Sucrose (pH 7.2)

Host cell:
HEK293T

Transfection:
Expression vector containing full-length human RXFP3 cDNA (GenBank accession number: NM_016568.2) with FLAG tag sequence at N-terminus

Recommended Storage:
Liquid nitrogen upon receiving

Data Sheet

Background: The relaxin family peptide receptor RXFP3, also known as GPCR135, RLN3R1 or SALPR, is a 469-amino acid, 7-transmembrane protein. RT-PCR detected RXFP3 expression in various sections of the brain and the testis. RXFP3 is known to be important to several functions of the central nervous system, especially sensory processing under stressful conditions.

Figure 1. Receptor expression on cell surface measured by flow cytometry (FACS) using an anti-FLAG antibody. Thin line: parental cells; thick line: receptor-expressing cells.

References:

Cgen et al. (2005) Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species. J Pharmacol Exp Ther 312:83-95.

Liu et al. (2003) Identification of relaxin-3/INSL7 as an endogenous ligand for orphan G-protein-coupled receptor GPCR135. J Biol Chem 278:50754-50764.

FOR RESEARCH USE ONLY.
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